Sickle Cell Disease (SCD) – Overview

Sickle Cell Disease (SCD) is a genetic blood disorder caused by a mutation in the hemoglobin gene, which results in the production of abnormal hemoglobin S.

Health Apr 21, 2025 19 Add to Reading List

This mutation leads to the formation of rigid, crescent-shaped red blood cells that block blood flow and reduce oxygen supply to the tissues. SCD is linked with chronic pain, anemia, an increased susceptibility to infections, organ damage, and other serious complications. It predominantly affects individuals of African, Mediterranean, Middle Eastern, and Indian descent. Treatment approaches aim to manage symptoms, prevent complications, and improve quality of life through advanced therapies and holistic care.

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Epidemiological Segmentation of SCD (2020–2034) – 6MM

Total Prevalence
Diagnosed Prevalence
Prevalence by SCD Type
Number of Treated Cases

SCD Epidemiology (2023 Insights)

In 2023, there were approximately 161,000 cases of Sickle Cell Disease across the six major markets (6MM).

The United States accounted for about 65% of these cases, representing a significant health burden.
In the U.S., the highest prevalence was observed in the 18–44 age group, underlining the impact of the disease on young, working-age individuals.

SCD Market Overview

The Sickle Cell Disease market in the 6MM was valued at roughly USD 650 million in 2023.

Market Drivers

Advances in gene-editing technologies and disease-modifying therapies are transforming the SCD treatment landscape, with the potential to offer long-term benefits.
Increased awareness, early diagnosis, and stronger support from governments and advocacy organizations are driving market growth and improving patient access.

Market Challenges

High treatment costs and inadequate healthcare infrastructure in lower-income regions limit access to advanced treatments.
Regulatory hurdles and complexities in clinical trials can slow the development and approval of new therapies.

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